Recent registry clean and malware removal, now freezing

I recently got the Vmonde and had it removed by working with the experts at the spybot.com forum. It seemed to work after that, so I gave the system back to my mom. It was running fine until she opened her Outlook and everything went awry. Striping on the monitor, frozen black screens, cursor that disappears, processes that halt and return. When booting, often, but not always goes to check disk, lines fill the screen. Mom wrote the message (partial)
vol ser # section 6CC5-1CE7, in case this is relevant. She hasn't gotten the blue screen of death, but it's currently kind of flipping out. Right now I have it on a defrag, if it doesn't freeze up first.

I had run a CCleaner and saved the registry entries, which I have on a thumb drive, but don't know how to post that, in case it's relevant. I ran the CCleaner before visiting spybot.com's forums, and they state my HiJackThis log looks clean.

I feel like I've done something to destablize her hard drive. What should I do to proceed, and should I finish the defrag first?