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Never do this.
Registry cleaners/optimizers are not recommended for several reasons:

• Registry cleaners are extremely powerful applications that can damage the registry by using aggressive cleaning routines and cause your computer to become unbootable.
  
  The Windows registry is a central repository (database) for storing configuration data, user settings and machine-dependent settings, and options for the operating system. It contains information and settings for all hardware, software, users, and preferences. Whenever a user makes changes to settings, file associations, system policies, or installed software, the changes are reflected and stored in this repository. The registry is a crucial component because it is where Windows "remembers" all this information, how it works together, how Windows boots the system and what files it uses when it does. The registry is also a vulnerable subsystem, in that relatively small changes done incorrectly can render the system inoperable. For a more detailed explanation, read Understanding The Registry.
  
• Not all registry cleaners are created equal. There are a number of them available but they do not all work entirely the same way. Each vendor uses different criteria as to what constitutes a "bad entry ". One cleaner may find entries on your system that will not cause problems when removed, another may not find the same entries, and still another may want to remove entries required for a program to work.
  
• Not all registry cleaners create a backup of the registry before making changes. If the changes prevent the system from booting up, then there is no backup available to restore it in order to regain functionality. A backup of the registry is essential BEFORE making any changes to the registry.
  
• Improperly removing registry entries can hamper malware disinfection and make the removal process more difficult if your computer becomes infected. For example, removing malware related registry entries before the infection is properly identified can contribute to system instability and even make the malware undetectable to removal tools.
  
• The usefulness of cleaning the registry is highly overrated and can be dangerous. In most cases, using a cleaner to remove obsolete, invalid, and erroneous entries does not affect system performance but it can result in "unpredictable results ".

Unless you have a particular problem that requires a registry edit to correct it, I would suggest you leave the registry alone. Using registry cleaning tools unnecessarily or incorrectly could lead to disastrous effects on your operating system such as preventing it from ever starting again. For routine use, the benefits to your computer are negligible while the potential risks are great.

• Ed Bott's Webog: Why I don't use registry cleaners
• Do I need a Registry Cleaner?

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You've been to malware removal forum before so you should know what to do.

Please, complete all steps listed HERE

Please, observe following rules:

• Read all of my instructions very carefully. Your mistakes during cleaning process may have very serious consequences, like unbootable computer.
• If you're stuck, or you're not sure about certain step, always ask before doing anything else.
• Please refrain from running tools or applying updates other than those I suggest.
• Never run more than one scan at a time.
• Keep updating me regarding your computer behavior, good, or bad.
• The cleaning process, once started, has to be completed. Even if your computer appears to act better, it may still be infected. Once the computer is totally clean, I'll certainly let you know.
• If you leave the topic without explanation in the middle of a cleaning process, you may not be eligible to receive any more help in malware removal forum.
• I close my topics if you have not replied in 5 days. If you need more time, simply let me know. If I closed your topic and you need it to be reopened, simply PM me.

 

Very well then.....