Internet Explorer taken over by Ad Boxes?

Here recently I have been on the net and out of nowhere my screen gets took over by these IE boxes, they pop up to many to fast to close them, so I have to unplug my PC, they say at the top no Ad to display or Ad cannot be displayed, and in the search bar of all the boxes is has tribalfusion, but the IE boxes are all blank, I run spybot, Webroot spysweeper full version, and SBC online protection with antivirus,antispy and popup blocker, I also run ZoneAlarm free version, I am running on windows SP1 if that helps, I am new to all this so please forgive me if I have not provided all the information, thanks in advance for any help you can provide, also I run every full scan of everything I have and none of them show anything.

 

You might want to consider three other programs: Ad-aware (a free anti-spyware program), Sunbelt's CounterSpy (an excellent anti-spyware program that is relatively inexpensive) AND most importantly (in my opinion), dumping IE and downloading and installing Firefox as your default browser. Obviously you cannot uninstall IE BUT you can set Firefox as your default. This should greatly reduce if not entirely eliminate these unwanted pop-up boxes. I never get them so you shouldn't either. It sounds, however, like you're going to have quite a clean-up job before you have this sort of freedom.