internet explorer problems

Every time I am on my computer more than 15 min. an orange box comes up on my task bar and goes through a bunch of numbers disturbing my usage and then a blank screen comes up with an address saying About: Blank how do I stop this?

 

Based on "orange box" and "opens a blank IE window," I'm going to guess it's spyware.

Download, install, immediately update and then run Spybot and/or AdAware. Read the help files to familiarize yourself with how they work. I recommend you use them both since each tends to find things the other misses. Let them clean up any spyware found.

Then, to be doubly sure, download and run CWShredder and run it (link to the download is near the bottom of the page).