I'd uninstall Ad-aware and Spybot as tools of the past and I'd add Malwarebytes' Anti-Malware (trial version is fully functionable): http://www.malwarebytes.org/mbam.php to your arsenal.
Program like CCleaner should be run weekly. Just make sure, you don't touch registry part.
Download Temp File Cleaner (TFC)
Double click on TFC.exe to run the program.
Click on Start button to begin cleaning process.
TFC will close all running programs, and it may ask you to restart computer.