Thanks for your replies guys.
As far as disk cleanup and defrag go, I do that quite regularly. I ran both again yesterday, but with little effect on startup. As far as my HDD
goes, I'm only using about 6% of the drive. I also ran Hitman Pro for what it's worth.
When I first power up the machine, it will hang on the first splash screen (Asus mobo
splash screen) for at least a few minutes. If I leave it alone it will eventually post. If I tab from the flash screen early on, it will post (start to post) almost immediately.
Once the machine starts posting (if I tab from the splash screen), I immediately get a message for the processor (AMD
N.B.), initializing USB controller, and memory (2048 MB ok). From there posting slows to a crawl and usually requires a few minutes to finish. Once the OS splash screen appears, things move fairly quickly.
Hope that helps. Thanks again!