Other SoftwarePost questions here about stuff not directly related to a specific OS (Applications, Games).
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With a properly maintained system, my answer would be no. I have had to use them on other's computers (to save time) but have never liked them and they can be very dangerous with inexperienced hands.
I agree with both wildfire and dobhar - not needed in general usage - can do more harm than good and you will not see any difference in performance after using There are odd exceptions - example to clear out references to an uninstalled program which may prevent a later version from loading.