heh, I've owned Micemen for years (and I've been stuck on it for years also), always been able to back out of it though.
If ALT+F4 or ESC definitely does not work... Find out the specs of your wifes PC. IE what operating system, processor, etc. If it's recent enough, ever considered DOS emulation software? Quite useful if you have trouble quitting, as you can set it to open in a window so it's easy to close.
However, unfortunately, much DOS emulation software requires fairly high processor power etc.